Notably, these side effects only occured at the highest dose and also only occurred in a variant of DIM that had been specifically engineered for rapid absorption and bioavailability. This family of greens includes Brussels sprouts, kale, broccoli, watercress, and collard greens, to name a few. Nutricost DIM is high-potency and pure. A new European formula is now sold on the Amazon UK and EU marketplaces. To help you in your search, we have completed this list of the Best Dim Supplement For Men 100mg. DIM’s mechanism of action has been linked to hormonal functions in the thyroid, but its action in people who have mild hypothyroid, or hyperthyroid, is unknown. If you've ever shopped on Amazon you know there are thousands of choices when it comes to supplements. It also exerts more general anti-inflammatory effects that might be useful for health conditions characterized by a lot of systemic inflammation, including digestive tract problems like irritable bowel syndrome, or IBS. well at high doses, triggering side effects when the dose of DIM is 300 mg or more. Evidence from mammary cell lines has demonstrated the role of DIM in reducing oxidative stress and demonstrating a role in reducing cyclooxygenase-2–induced inflammation in mammary cell lines. The best approach that will generate the fastest and most profound changes is when you combine diet changes with supplements. Indeed, DIM has been found to block estrogen receptors in certain studies, which may reduce the effects of estrogen on your system, even though it may not lower your blood levels of estrogen per se. Nature’s Way has a DIM formulation that is specially designed for processing estrogen. Once you take a dose of it, your body has fully absorbed the compound within two hours or so. Ideal for you, if: Top Rated Best Dim Supplement For Men 100mg Of 2021. How do you know what’s the best one to take? Smoky Mountains has a good dose of DIM with 200 mg of DIM plus 2.5 mg of BioPerine per capsule. A: The utility of DIM as a supplement for men revolves around its potential ability to act as an estrogen blocker. It should be emphasized that this effect is largely theoretical, though this has not stopped it from being adopted widely by men looking to. These results suggest that DIM may be a future adjuvant therapy for periodontal diseases. A 2015 study evaluated the effect of DIM on bone mass in mice. level of estrogen experienced by your body (as the action of some amount of the actual estrogen in your body would be “blocked” by DIM). The capsules are vegetarian-friendly, and though there are a couple of extra binders included, it’s still a solid pick for a DIM supplement. We found hormone modulators, like vitamin D, to be helpful, while bunders or stabilizing agents meant that a particular DIM supplement scored lower in the final rankings. While the findings that support this come only from very small studies, mostly on cancer patients, the implication is that DIM could lower the. Q: How long does it take for DIM to work? DIM might be part of why cruciferous vegetables reduce the risk of cancer. In addition, downregulation of NF-κB and AP-1 signaling (mediators of inflammatory responses) contributes to the anti-inflammatory actions of DIM (10). Diindolylmethane (DIM) is a versatile nutraceutical for which I find many uses in my practice. One of the most popular DIM supplements is from Smoky Mountain Naturals. We allowed products with additional potentially useful ingredients, such as vitamin D or aids to bioavailability such as BioPerine (a proprietary black pepper extract). BioPerine has been shown to increase the bioavailability of DIM for better absorption. It has 100 mg of DIM per capsule, and no unnecessary ingredients—just gelatin for the capsule and rice flour to fill out the rest of the space inside the capsule. DIM supplements are being studied for their protective effects against certain cancers. With that being said, everyone has their own body chemistry and it is important to consult a physician to ensure you are taking the proper dose that will give you positive effects instead of side effects. A patent for this application was registered in 2008, and cites potential biological mechanisms by which DIM could assist with treating the HPV virus (12). Best DIM for oxidative damage and inflammation: Zhou DIM Active. For BodyNutrition‘s #1 DIM recommendation, click. In combination with Taxotere, a concentration of 40μM DIM resulted in a 78 percent inhibition of growth and a decreased invasive capacity of the aggressive breast cancer cell line MDA-MB-231 (4). Best Dim Supplement In January 2021. Yes, DIM really does work if you take it correctly and at the right dose. DIM’s action inside the body is fairly well-understood, at least in terms of its short-term effects and bioavailability, so we had a very narrow range of DIM doses in mind. aSquared Nutrition is a solid source of DIM if you are looking for a supplement that has a low dose and no additional ingredients. DrFormulas is a very popular DIM supplement that includes BioPerine for superior absorption and delivers 100 mg of DIM per capsule. Symptoms of estrogen dominance include fatigue, mood swings, acne, bloating, and especially fat gain around the abdominal area. DIM has been shown in clinical studies to promote healthier estrogen metabolism in both men and women. A: DIM is excreted from your body fairly quickly. Indole 3-Carbinol, also known as I3C, is a naturally-resulting compound that comes from eating cruciferous vegetables such as broccoli, cauliflower, and cabbage. For more pronounced results the bottle says to take double the recommended dose. As it is an acid it a detriment to absorption of the other ingredients. Nutricost DIM is maximum strength – providing 300mg per capsule of DIM as well as BioPerine to help with maximum absorption. This product is micro-encapsulated to aid in absorption. It is the only estrogen blocker on this list that does not contain BioPerine. With a minimum of additional ingredients, you don’t have to worry about interactions with other supplements that you may be taking. If you are ready to choose a new Best Dim Supplement For Men 100mg, check out our detailed recommendation below!. Zhou Nutrition DIM Active includes broccoli extract alongside a high dose of DIM to support estrogen metabolism and turnover, making it perfect for women. It has been shown in studies that vitamin C may have a possible interaction with estrogen however Zhou Active only contains 60mg which is not enough to have an actual effect. All of these supplements could be helpful for PMS, menopause, and balancing estrogen. DIM helps balance, normalize and improve estrogen metabolism in men and women. However, specific types of cancer that are known to be linked to estrogen, like breast cancer or ovarian cancer, have not been definitely linked to cruciferous vegetable intake or DIM intake, so more research needs to be done to confirm this link. Several clinical trials have been conducted using DIM, and the aggregation of these trials gives some insights into the best way to take DIM for maximum efficacy. Every now and then, I like to highlight a particular supplement that my audience may not be aware of, and go in-depth about its uses, benefits, and potential drawbacks. To that end, we dropped products that had a high dose of DIM alongside aids for absorption. Several trials evaluating the role of DIM in breast cancer prevention are currently under way. DIM Supplement 250mg Plus BioPerine, Broccoli Sprouts Seed | Best DIM with Sulforaphane. Supplements are your amplifiers and healing accelerators. If you take more than 1 capsule per day you will be going through the container pretty quickly. In another study, researchers concluded that DIM can inhibit inflammation of the periodontal tissue in mice after one week of treatment, which promoted alveolar bone recovery in the experimental periodontitis mouse model (9). If you take a look at the Amazon listing for Nutricost DIM you will see there is very little written about the effects of the supplement and what it is promoted for. The estrogen-related mechanism behind DIM’s potential benefit for fighting cancers has led to additional research that may support a use for DIM in treating the human papillomavirus, or HPV, a viral infection that can cause genital warts and cervical cancer (hence the DIM/estrogen connection). Its DIM dosage is low, at 100 mg per capsule, but it also provides lecithin from soybeans to support estrogen function and BioPerine for superior bioavailability and vitamin E for added antioxidant power. Genius DIM only contains 30 capsules per bottle which is the least lasting product on the list. There are people who feel effects from DIM within the first few days of taking it while others may need a couple of weeks for it to build up in their body. However, other studies have been a month or more, so count on it taking at least a few weeks for DIM to start working. By far the best natural source for DIM is found in cruciferous vegetables. Furthermore, some studies (albeit small pilot studies) have found that biological effects attributable to DIM start appearing within two weeks of starting to take DIM. Some DIM supplements work better than others depending on the ingredients, potency, and for the specific reason someone might take it. 95 ($0.32/Count) It is believed DIM interacts with cytochrome P450 substrates (enzymes essential for the metabolism of medications); DIM may affect the serum concentration of drugs metabolized by this enzyme. A 2016 review published in Nutrition Reviews journal described current evidence related to the metabolism and mechanisms of this compound’s involvement in the prevention of breast cancer. Other research into the safety of DIM has reported that headaches and vomiting can occur with DIM, but this study only noted them at high doses (300 mg taken all at once) (17). Zhou’s solution is to provide DIM (at a strong dose of 250 mg) alongside broccoli seed extract, vitamin C, and vitamin E. The hope here is that the combined action of these ingredients will result in better outcomes than just consuming DIM by itself. HIGH-QUALITY DIM. It also contains 2.5mg of Bioperine which doesn't have any effect on lowering estrogen. A: DIM is popular as a supplement that may target and slow or prevent the growth of certain cancerous cells, at least in preliminary research. Key Products I Recommend: #1 DIM. Also, the DIM supplement additionally influences testosterone, a hormone that is connected to zits. The cruciferous vegetable family, which includes broccoli, cauliflower, kale, bok choy, cabbage, has been associated with a reduced risk of cancer in numerous epidemiological studies (. Smoky Mountain has 200mg of DIM which may be strong for some people who are just starting out taking it. Evolved Organics Extra Strength DIM is the #1 Best Seller on Amazon under the Dong Quai Herbal Supplements with a 4.5 Star rating, giving this supplement the rightful #2 spot on our list. Let us know about your experience in the comments below. If you choose to live a vegetarian or vegan lifestyle, then Solaray DIM Supreme may be the DIM supplement just for you. While the evidence thus far is limited to small pilot studies, or animal model and cellular studies, DIM has nevertheless shown promise as a way to target malignant cells and slow or stop their growth. right away in the morning) or split your dosage up into two doses, taken in the morning and in the evening. Have you tried Estrohalt or any of these DIM products? With the number of alternatives available on the market, getting the right one could sometimes be a difficult task.. That’s why our platform is dedicated to product testing and coming up with this list of top 10 Best Dim Supplement. At 250 mg per capsule, the DIM content is still solid. Researchers concluded that DIM inhibits prostate carcinogenesis via induction of apoptosis and inhibition of cell cycle progression, and induces the death of prostate cancer cells via the mitochondria- and death receptor-mediated pathways (2). If these benefits are what you are looking for, our research team has ranked the ten best DIM supplements on the market according to purity and efficacy. It’s widely reputed as a strong anti-cancer agent that can also be used to reduce inflammation and detox your body thanks to the biological activity of DIM. We suggest buying Estrohalt as it has better bioavailability, less adverse reactions, and a more attractive price compared to other estrogen blockers that are sold. Dim supplement. There are many different brands selling DIM. Estrohalt was the #1 best selling dim supplement on Amazon UK, but unfortunately Amazon UK has recently banned the sale of all products containing DIM as DIM can no longer be sold. As like other DIM supplements we believe their product is for reducing estrogen. Once you take a dose of it, your body has fully absorbed the compound within two hours or so. DIM may act against the HPV virus. Buy Smoky Mountain Nutrition DIM Complex. For those who cannot swallow capsules, the product can be opened, allowing access to the powder inside. For women: the supplement was designed to help with menopause symptoms and PCOS. This family of greens includes Brussels sprouts, kale, broccoli, watercress, and collard greens, to name a few. We think Grapeseed extract is a beneficial ingredient for reducing estrogen as it has been shown to be an aromatase inhibitor which stops androgens from converting to estrogen in the body. It does not directly lower the levels of estrogen in your body, but it might be able to block estrogen receptors in your body, which would reduce the effective level of estrogen that you are exposed to. From our research BioPerine increases the bioavailability of B-vitamins which none of these dim supplements contain. Best DIM supplement. Rating: 4.5 stars. A 2011 study set out to examine whether DIM inhibits the development of prostate cancer using an adenocarcinoma mouse prostate model. Diindolylmethane, or DIM for short, is a natural compound that’s found in copious quantities in cruciferous vegetables like broccoli, kale, Brussel sprouts, and bok choy. Diet is your foundation. Genius Estrogen Balance – DIM Supplement w/ Grape Seed Extract. When we reviewed this product it was still called Dynamic Nutrition DIM, but as of recent they have changed the name to Effective Nutra. DrFormulas DIM Supplement is one of the best skin supplements for cystic acne that provide DIM hormonal support. DIM Plus appears to be available in capsule form only. These findings suggest either taking a 150 mg dosage once per day, or a 100 mg dosage in the morning and the evening, for maximum efficacy. Estrogen dominance occurs when there is an excess amount of estrogen in the body and effects both women and men. This supplement includes glucoraphanin at a concentration of 5% that is converted into sulforaphane after ingestion. Another sign of balanced estrogen levels is better sleep quality so DIM can help in that sense too. DIM’s efficacy appears to be pretty rapid. A: In the context of thyroid function, DIM has only been researched as a potential way to slow the growth of thyroid tumors. You can learn more about Smoky Mountain Naturals’ DIM Supplement on Amazon. Researchers also noted that 10 μM DIM inhibited proliferation by 55 percent after four days and by 60 percent after six days of treatment. A: DIM stands for diindolylmethane, which is a molecular compound found in vegetables from the cruciferous vegetable family. It includes no animal by-products and the included ingredients get encapsulated in a veggie based coating. Furthermore, administration of DIM in ovariectomized mice (ovariectomy induced bone loss in rats and postmenopausal bone loss in women share many similar characteristics) effectively prevented bone loss resulting from increased bone resorption (7,8). This pins Nature’s Way DIM-plus Estrogen Metabolism into a fairly niche use category, making it difficult to recommend for most people. This product is also geared toward both women and men to help inhibit excess estrogen, provide menopause relief, reduce hot flashes, boost weight loss and restore clarity. Buy DIM (Diindolylmethane), Supplements and Vitamins & Supplements from HealthyPlanetCanada.com at a discounted price (up to 50% off). Thereafter, we looked at the supplement design and the presence of any potential ingredients to boost efficacy. Other work by researchers at the University of Kansas Medical Center on the absorption bioavailability of DIM gives further insights into the range of doses that’s likely to be tolerable (18). Estrohalt is our number one pick for best dim supplement because of the quality of ingredients, price, and effectiveness. 300 Mg Per Serving; 120 Capsules/Servings Per Bottle; Bioperine Added For Maximum Absorption; Nutricost DIM provides a high quality DIM (Diindolymethane) product at an affordable price. It’s found heavily in superfood green drinks, too. DIM is excreted from your body fairly quickly. This means that it’s important to either take DIM at the same time every day (e.g. DIM may reduce the invasive and metastatic potential of breast tumors. DIM has also been shown to induce Multidrug Resistance Protein and can affect the transport of drugs mediated by this protein (16). We recommend Smoky Mountains Nutrition DIM for this purpose, thanks to its moderate dosage and high purity. Studies have not yet compared whether it’s better to take one individual dose of DIM per day or split it into two, but we do know that taking less than 100 mg of DIM at a time is not recommended, as doses lower than this do not generate detectable levels of DIM in the bloodstream. In addition, the supplement design isn’t very clean; there’s a lot of extra binders and excipients included that hurt the product’s purity. It boasts an industry-leading 300 mg of DIM per capsule and 5 mg of BioPerine for maximum absorption. Infographic: Eating Under Quarantine… While supplements that had ingredients to boost bioavailability can be useful, we noted that some research indicates that these agents can work too well at high doses, triggering side effects when the dose of DIM is 300 mg or more. After you take DIM, it reaches a peak concentration in your blood within two hours or so; every four hours after that, your levels of DIM are cut in half. It is sold worldwide including on Amazon US and AU. This makes it possibly more useful for hormonal conditions, but less versatile than some of its competitors without these additional ingredients. This makes it well-suited for women who use DIM for treating premenstrual syndrome, and possibly for other estrogen-related issues. This compound also plays a role in preventing bone loss and has anti-inflammatory properties. Rad on for our rankings. DIM interacts with estrogen, and many types of tumors are activated by this same hormone, so research papers have proposed a connection between DIM, estrogen, and cancer risk. DIM can be considered an anti-initiating breast tumor agent through its ability to stimulate cellular detoxification pathways. The cruciferous vegetable family, which includes broccoli, cauliflower, kale, bok choy, cabbage, has been associated with a reduced risk of cancer in numerous epidemiological studies (11). Diindolylmethane exhibits anti-tumor activity in prostate cancer models. It is naturally obtained via dietary consumption of cruciferous vegetables. The timing of exactly when you take DIM is less important than the consistency with which you take it. People whose diets are high in these vegetables appear to have lower rates of certain cancers, which has led researchers to search for biochemical reasons why these vegetables might help prevent regrowth of cancerous cells. DIM is a supplement that is has a small number of highly specific and targeted applications. It’s been heavily researched as a possible anticancer compound, and appears to exert estrogen blocking effects in some studies as well. Rash has also been reported and DIM may cause hormonal disturbances (15). Best DIM for women: Zhou Nutrition DIM Active. According to Dr. Ronald Homman, a complementary medicine practitioner, researchers prefer standardized BioResponse DIM. Nature's Way DIM Plus is another supplement that is a capsule, so again you cannot break it in half to judge the strength. This is sound reasoning, but clinical studies do tend to look at DIM in isolation, so whether you want to go with this supplement depends on your supplementation philosophy. Because DIM’s optimal dosage is so small, you’ll need a milligram-accurate scale to measure out the right dosage. While many people would like to see more studies. CONCLUSION: Our Recommendation is Estrohalt. We've listed here what we think are the 7 best DIM supplements on Amazon so you can make an informed decision about the best one for your body's needs. Medical professionals have long stressed the link between eating a diet high in vegetables and the prevention of many types of cancers. We read in some reviews that some customers needed to take 4 capsules a day to feel any effects while others became ill and experienced hair loss. Zhou DIM Active pairs 250 mg of DIM with three synergistic antioxidants and anti-inflammatories: vitamin C, vitamin E, and broccoli seed extract. Cells were treated with either a range of concentrations of DIM for 24 hours or with 10 μM DIM for up to 6 days. Nutricost, with 300 mg of DIM per capsule, is perfectly suited for the task. We don’t suggest this supplement for new time users because of the high amount of DIM which could be detrimental. Diindolylmethane has anti-inflammatory properties. In addition to having anticancer effects, it has been shown to have anti-inflammatory effects and the ability to increase bone mass in animal studies. The capsules are vegetarian-friendly, and though there are a couple of extra binders included, it’s still a solid pick for a DIM supplement. A: By far the best natural source for DIM is found in cruciferous vegetables. Results indicated that after 24 hours of treatment, DIM suppressed growth cell growth by 20 and 40 percent with 10 and 30 μM concentrations, respectively. Di-Indole Methane is the direct metabolite of I3C (Indole-3-Carbinol) and twice as strong. For this reason it may or may not increase absorption of other ingredients. It will likewise urge estrogen to separate into the ‘great’ metabolites as opposed to the ‘terrible’ ones. This combination supplement includes diindolymethane, dong quai, vitamin E, and Bioperine, making this a versatile supplement. Beyond potential anticancer effects, DIM has been investigated for activity against the HPV virus, with mixed success. As with all other supplements, not all are equal. Source Naturals DIM is a formulation specifically made to support breast health. Some reported side effects include darkening of urine, increase in bowel frequency, headache and excess gas (14). The estrogen-related mechanism behind DIM’s potential benefit for fighting cancers has led to additional research that may support a use for DIM in treating the human papillomavirus, or HPV, a viral infection that can cause genital warts and cervical cancer (hence the DIM/estrogen connection). Interestingly, DIM’s ability to act against estrogen is one of the potential avenues that it may use to fight cancerous cells. It’s a good choice for women looking to optimize breast health, but for all-around DIM versatility, it’s not the best. Zhou attempts to rectify one of the recurrent limitations with compounds isolated from healthy foods—when you take just one chemical out of a healthy food, you lose some of the synergy between the other compounds found in the food. Macrophages are the main pro-inflammatory cells that respond to invading pathogens by releasing many pro-inflammatory molecules, including nitric oxide and prostaglandins.